Antibiotic-Selected Gene Amplification Heightens Metal Resistance
نویسندگان
چکیده
منابع مشابه
Co-selection of antibiotic and metal resistance.
There is growing concern that metal contamination functions as a selective agent in the proliferation of antibiotic resistance. Documented associations between the types and levels of metal contamination and specific patterns of antibiotic resistance suggest that several mechanisms underlie this co-selection process. These co-selection mechanisms include co-resistance (different resistance dete...
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The use of beta-lactam antibiotics has led to the evolution and global spread of a variety of resistance mechanisms, including beta-lactamases, a group of enzymes that degrade the beta-lactam ring. The evolution of increased beta-lactam resistance was studied by exposing independent lineages of Salmonella typhimurium to progressive increases in cephalosporin concentration. Each lineage carried ...
متن کاملGene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate.
Leishmania tarentolae promastigotes were selected step by step for resistance to sodium stibogluconate (Pentostam). Mutants resistant to antimony-containing drugs and cross-resistant to arsenite were therefore obtained. Amplification of one common locus was observed in several independent sodium stibogluconate-resistant mutants, and the locus amplified was novel. The copy number of the amplifie...
متن کاملParallel evolutionary pathways to antibiotic resistance selected by biocide exposure
OBJECTIVES Biocides are widely used to prevent infection. We aimed to determine whether exposure of Salmonella to various biocides could act as a driver of antibiotic resistance. METHODS Salmonella enterica serovar Typhimurium was exposed to four biocides with differing modes of action. Antibiotic-resistant mutants were selected during exposure to all biocides and characterized phenotypically...
متن کاملGene Amplification, Drug Resistance, and Cancer1
The finding that genetic alterations, i.e., mutations, can involve quantitative changes, as contrasted to the qualitative changes, in a genome was first made in Drosophila (88) and more recently has been examined extensively as a developmental process with ribosomal genes in amphibians (18; see Ref. 13 for review). The phenomenon of selective gene amplification in cultured mam malian cells was ...
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ژورنال
عنوان ژورنال: mBio
سال: 2021
ISSN: 2161-2129,2150-7511
DOI: 10.1128/mbio.02994-20